Sequence analysis of HIV‐1 isolates from Guinea‐Bissau: selection of vaccine epitopes relevant in both West African and European countries
Identifieur interne : 000867 ( Main/Exploration ); précédent : 000866; suivant : 000868Sequence analysis of HIV‐1 isolates from Guinea‐Bissau: selection of vaccine epitopes relevant in both West African and European countries
Auteurs : Lasse Vinner [Danemark] ; Birgitta Holmgren [Suède] ; Kristoffer J. Jensen [Danemark] ; Joakim Esbjornsson [Suède] ; Marie Borggren [Suède] ; Julie L. Hentze [Danemark] ; Ingrid Karlsson [Danemark] ; Betina S. Andresen [Danemark] ; Gregers J. Gram [Danemark] ; Henrik Kloverpris [Danemark] ; Peter Aaby ; Zacarias José Da Silva ; Eva-Maria Fenyö [Suède] ; Anders Fomsgaard [Danemark]Source :
- APMIS [ 0903-4641 ] ; 2011-08.
Descripteurs français
- Wicri :
- geographic : Danemark.
- topic : Base de données, Vaccination, Vaccin.
English descriptors
- KwdEn :
- Additional vaccine epitopes, Alamos database, Allele, Ambiguous positions, Apmis, Apmis epitopes, Authors apmis, Autologous dendritic cells, Available database sequences, Biochemical blood values, Biological characterization, Ccr5, Ccr5 usage, Chemokine receptors, Chimeric receptors, Coreceptor, Coreceptor chimer, Coreceptor tropism, Cxcr4, Cxcr4 usage, Database, Database reference sequences, Database sequences, Denmark, Direct immunity, Disease burden, Disease progression, Dual infections, Epitope, Epitope conservation, Ethnic groups, Genbank accession, General health status, Genome, Genome sequences, Geographic locations, Geographic regions, Host population, Human virus, Human virus type, Immune targets, Immunol, Immunol sidney, Light microscopy, Lund, Lund university, Monophyletic cluster, Neutnet report, Neutralization, Normal ranges, Other regions, Other west african countries, Peptide, Phylogenetic, Phylogenetic analysis, Phylogenetic relationship, Recombinant, Recombinant forms, Reference sequences, Retrovirus, Sequence analysis, Sequence information, Subdominant, Subtype, Subtypes, Supertype, Supertypes, Tissue types, Tree topology, Triplicate wells, Tropism, Vaccination, Vaccine, Vaccine epitope, Vaccine epitopes, Valuable information, Verbal consent, Vinner, Virol, Virus, Virus replication, Virus stocks, West africa, West african, West african countries.
- Teeft :
- Additional vaccine epitopes, Alamos database, Allele, Ambiguous positions, Apmis, Apmis epitopes, Authors apmis, Autologous dendritic cells, Available database sequences, Biochemical blood values, Biological characterization, Ccr5, Ccr5 usage, Chemokine receptors, Chimeric receptors, Coreceptor, Coreceptor chimer, Coreceptor tropism, Cxcr4, Cxcr4 usage, Database, Database reference sequences, Database sequences, Denmark, Direct immunity, Disease burden, Disease progression, Dual infections, Epitope, Epitope conservation, Ethnic groups, Genbank accession, General health status, Genome, Genome sequences, Geographic locations, Geographic regions, Host population, Human virus, Human virus type, Immune targets, Immunol, Immunol sidney, Light microscopy, Lund, Lund university, Monophyletic cluster, Neutnet report, Neutralization, Normal ranges, Other regions, Other west african countries, Peptide, Phylogenetic, Phylogenetic analysis, Phylogenetic relationship, Recombinant, Recombinant forms, Reference sequences, Retrovirus, Sequence analysis, Sequence information, Subdominant, Subtype, Subtypes, Supertype, Supertypes, Tissue types, Tree topology, Triplicate wells, Tropism, Vaccination, Vaccine, Vaccine epitope, Vaccine epitopes, Valuable information, Verbal consent, Vinner, Virol, Virus, Virus replication, Virus stocks, West africa, West african, West african countries.
Abstract
Vinner L, Holmgren B, Jensen KJ, Esbjornsson J, Borggren M, Hentze JL, Karlsson I, Andresen BS, Gram GJ, Kloverpris H, Aaby P, da Silva ZJ, Fenyö E‐M, Fomsgaard A. Sequence analysis of HIV‐1 isolates from Guinea‐Bissau: selection of vaccine epitopes relevant in both West African and European countries. APMIS 2011; 119: 487–97. For a CD8 epitope‐based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T‐lymphocytes (CTLs) must be present in the local circulating HIV‐1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV‐1 isolates from Guinea‐Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super‐types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.
Url:
DOI: 10.1111/j.1600-0463.2011.02763.x
Affiliations:
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Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">APMIS</title><title level="j" type="alt">APMIS</title><idno type="ISSN">0903-4641</idno><idno type="eISSN">1600-0463</idno><imprint><biblScope unit="vol">119</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="487">487</biblScope><biblScope unit="page" to="497">497</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-08">2011-08</date></imprint><idno type="ISSN">0903-4641</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0903-4641</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Additional vaccine epitopes</term><term>Alamos database</term><term>Allele</term><term>Ambiguous positions</term><term>Apmis</term><term>Apmis epitopes</term><term>Authors apmis</term><term>Autologous dendritic cells</term><term>Available database sequences</term><term>Biochemical blood values</term><term>Biological characterization</term><term>Ccr5</term><term>Ccr5 usage</term><term>Chemokine receptors</term><term>Chimeric receptors</term><term>Coreceptor</term><term>Coreceptor chimer</term><term>Coreceptor tropism</term><term>Cxcr4</term><term>Cxcr4 usage</term><term>Database</term><term>Database reference sequences</term><term>Database sequences</term><term>Denmark</term><term>Direct immunity</term><term>Disease burden</term><term>Disease progression</term><term>Dual infections</term><term>Epitope</term><term>Epitope conservation</term><term>Ethnic groups</term><term>Genbank accession</term><term>General health status</term><term>Genome</term><term>Genome sequences</term><term>Geographic locations</term><term>Geographic regions</term><term>Host population</term><term>Human virus</term><term>Human virus type</term><term>Immune targets</term><term>Immunol</term><term>Immunol sidney</term><term>Light microscopy</term><term>Lund</term><term>Lund university</term><term>Monophyletic cluster</term><term>Neutnet report</term><term>Neutralization</term><term>Normal ranges</term><term>Other regions</term><term>Other west african countries</term><term>Peptide</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic relationship</term><term>Recombinant</term><term>Recombinant forms</term><term>Reference sequences</term><term>Retrovirus</term><term>Sequence analysis</term><term>Sequence information</term><term>Subdominant</term><term>Subtype</term><term>Subtypes</term><term>Supertype</term><term>Supertypes</term><term>Tissue types</term><term>Tree topology</term><term>Triplicate wells</term><term>Tropism</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine epitope</term><term>Vaccine epitopes</term><term>Valuable information</term><term>Verbal consent</term><term>Vinner</term><term>Virol</term><term>Virus</term><term>Virus replication</term><term>Virus stocks</term><term>West africa</term><term>West african</term><term>West african countries</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additional vaccine epitopes</term><term>Alamos database</term><term>Allele</term><term>Ambiguous positions</term><term>Apmis</term><term>Apmis epitopes</term><term>Authors apmis</term><term>Autologous dendritic cells</term><term>Available database sequences</term><term>Biochemical blood values</term><term>Biological characterization</term><term>Ccr5</term><term>Ccr5 usage</term><term>Chemokine receptors</term><term>Chimeric receptors</term><term>Coreceptor</term><term>Coreceptor chimer</term><term>Coreceptor tropism</term><term>Cxcr4</term><term>Cxcr4 usage</term><term>Database</term><term>Database reference sequences</term><term>Database sequences</term><term>Denmark</term><term>Direct immunity</term><term>Disease burden</term><term>Disease progression</term><term>Dual infections</term><term>Epitope</term><term>Epitope conservation</term><term>Ethnic groups</term><term>Genbank accession</term><term>General health status</term><term>Genome</term><term>Genome sequences</term><term>Geographic locations</term><term>Geographic regions</term><term>Host population</term><term>Human virus</term><term>Human virus type</term><term>Immune targets</term><term>Immunol</term><term>Immunol sidney</term><term>Light microscopy</term><term>Lund</term><term>Lund university</term><term>Monophyletic cluster</term><term>Neutnet report</term><term>Neutralization</term><term>Normal ranges</term><term>Other regions</term><term>Other west african countries</term><term>Peptide</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic relationship</term><term>Recombinant</term><term>Recombinant forms</term><term>Reference sequences</term><term>Retrovirus</term><term>Sequence analysis</term><term>Sequence information</term><term>Subdominant</term><term>Subtype</term><term>Subtypes</term><term>Supertype</term><term>Supertypes</term><term>Tissue types</term><term>Tree topology</term><term>Triplicate wells</term><term>Tropism</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine epitope</term><term>Vaccine epitopes</term><term>Valuable information</term><term>Verbal consent</term><term>Vinner</term><term>Virol</term><term>Virus</term><term>Virus replication</term><term>Virus stocks</term><term>West africa</term><term>West african</term><term>West african countries</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Base de données</term><term>Vaccination</term><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vinner L, Holmgren B, Jensen KJ, Esbjornsson J, Borggren M, Hentze JL, Karlsson I, Andresen BS, Gram GJ, Kloverpris H, Aaby P, da Silva ZJ, Fenyö E‐M, Fomsgaard A. Sequence analysis of HIV‐1 isolates from Guinea‐Bissau: selection of vaccine epitopes relevant in both West African and European countries. APMIS 2011; 119: 487–97. For a CD8 epitope‐based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T‐lymphocytes (CTLs) must be present in the local circulating HIV‐1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV‐1 isolates from Guinea‐Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super‐types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Suède</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><noCountry><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name><name sortKey="Da Silva, Zacarias Jose" sort="Da Silva, Zacarias Jose" uniqKey="Da Silva Z" first="Zacarias José" last="Da Silva">Zacarias José Da Silva</name></noCountry><country name="Danemark"><region name="Hovedstaden"><name sortKey="Vinner, Lasse" sort="Vinner, Lasse" uniqKey="Vinner L" first="Lasse" last="Vinner">Lasse Vinner</name></region><name sortKey="Andresen, Betina S" sort="Andresen, Betina S" uniqKey="Andresen B" first="Betina S." last="Andresen">Betina S. Andresen</name><name sortKey="Fomsgaard, Anders" sort="Fomsgaard, Anders" uniqKey="Fomsgaard A" first="Anders" last="Fomsgaard">Anders Fomsgaard</name><name sortKey="Gram, Gregers J" sort="Gram, Gregers J" uniqKey="Gram G" first="Gregers J." last="Gram">Gregers J. Gram</name><name sortKey="Hentze, Julie L" sort="Hentze, Julie L" uniqKey="Hentze J" first="Julie L." last="Hentze">Julie L. Hentze</name><name sortKey="Jensen, Kristoffer J" sort="Jensen, Kristoffer J" uniqKey="Jensen K" first="Kristoffer J." last="Jensen">Kristoffer J. Jensen</name><name sortKey="Karlsson, Ingrid" sort="Karlsson, Ingrid" uniqKey="Karlsson I" first="Ingrid" last="Karlsson">Ingrid Karlsson</name><name sortKey="Kloverpris, Henrik" sort="Kloverpris, Henrik" uniqKey="Kloverpris H" first="Henrik" last="Kloverpris">Henrik Kloverpris</name></country><country name="Suède"><noRegion><name sortKey="Holmgren, Birgitta" sort="Holmgren, Birgitta" uniqKey="Holmgren B" first="Birgitta" last="Holmgren">Birgitta Holmgren</name></noRegion><name sortKey="Borggren, Marie" sort="Borggren, Marie" uniqKey="Borggren M" first="Marie" last="Borggren">Marie Borggren</name><name sortKey="Esbjornsson, Joakim" sort="Esbjornsson, Joakim" uniqKey="Esbjornsson J" first="Joakim" last="Esbjornsson">Joakim Esbjornsson</name><name sortKey="Fenyo, Eva Aria" sort="Fenyo, Eva Aria" uniqKey="Fenyo E" first="Eva-Maria" last="Fenyö">Eva-Maria Fenyö</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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